rs13207033
A SNP on chromosome 6. Its most notable genotype is A;A: reduced risk of rheumatoid arthritis
- Gene
- None listed
- Location
- Chr 6137,644,281 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 19%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableGoodreduced risk of rheumatoid arthritis
- A;GNot ratedNo summary available.
- G;GBadnormal
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 4% A;G 28% G;G 68%
- European ancestry (Utah)A;A 8% A;G 31% G;G 61%
- Han Chinese (Beijing)A;A <1% A;G 18% G;G 82%
- Japanese (Tokyo)A;A <1% A;G 17% G;G 82%
- Yoruba (Nigeria)A;A 1% A;G 18% G;G 81%
- African ancestry (Southwest US)A;A 4% A;G 28% G;G 68%
- Chinese (Denver)A;A 0% A;G 19% G;G 81%
- Gujarati IndianA;A 16% A;G 44% G;G 41%
- Luhya (Kenya)A;A 0% A;G 14% G;G 86%
- Mexican ancestry (Los Angeles)A;A 7% A;G 48% G;G 45%
- Maasai (Kenya)A;A 2% A;G 26% G;G 72%
- TuscanA;A 8% A;G 45% G;G 47%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 130 words
rs13207033 can be considered a proxy for rs10499194, since it is perfectly correlated to it (r 2 =1). In WTCCC data, the minor allele of rs13207033 was seen to be less frequent in patients with rheumatoid arthritis than in controls, just as rs10499194 has been seen in other studies. rheumatoid arthritis *rs6920220 [P= 2.6 x 10(-6), OR 1.22 (1.13-1.33)]. *rs5029937 *rs13207033 protective [P= 0.0001, OR 0.86 (0.8-0.93)] perfectly correlated with rs10499194 The combination of the carriage of both risk alleles of rs6920220 and rs5029937 together with the absence of the protective allele of rs13207033 was strongly associated with RA when compared to carriage of none [OR of 1.86 (95% CI) (1.51-2.29)]. This equates to an effect size of 1.50 (95% CI 1.21-1.85)
Source and license
Adapted from rs13207033 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.