rs34210653

A SNP in the ALOX15 gene on chromosome 17. Its most notable genotype is A;A: Reduced risk for nasal polyps and chronic sinusitis

Gene
ALOX15
Location
Chr 174,632,019 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
1%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodnormal riskTypical · 0.0
  2. A;GNot rated1.6x increased risk for heart diseaseTypical · 0.0
  3. A;AMost notableGoodReduced risk for nasal polyps and chronic sinusitisWorth knowing · 2.0

SNPedia records rs34210653 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 150 words

rs34210653 is a SNP in the ALOX15 gene, either encoding a threonine or a methionine at position 560 of the corresponding protein. This SNP is also known as T560M; the more common (C) allele encodes the threonine, and the rarer (T) allele encodes the methionine. In mice, this protein appears to promote atherosclerosis, and mice completely lacking the entire gene are free of atherosclerosis. In contrast, rs34210653(T;T) humans, who effectively have a non-functioning variant, do not show a statistically significant decreased risk for coronary artery disease. And rs34210653(C;T) heterozygotes an increased risk of heart disease (adjusted odds ratio 1.62, p=0.02). In 2019, a study of ~10,000 patients concluded that rs34210653(T) confers significant protection against nasal polyps (OR 0.32, CI: 0.26-0.39, p = 8.0 × 10e−27) and chronic rhinosinusitis (OR 0.64, CI: 0.55-75, p = 1.1 × 10e−8).

Source and license

Adapted from rs34210653 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.