rs17465637

A SNP in the MIA3 gene on chromosome 1. Its most notable genotype is C;C: 1.34x higher risk for myocardial infarction

Gene
MIA3
Location
Chr 1222,650,187 (GRCh38)
Highest magnitude
1.3Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
45%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratedNo summary available.Typical · 0.031% of people
  2. A;CBad1.17x higher risk for myocardial infarctionMinor · 1.239% of people
  3. C;CMost notableBad1.34x higher risk for myocardial infarctionMinor · 1.330% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 31% A;C 39% C;C 30%
  • European ancestry (Utah)A;A 4% A;C 46% C;C 50%
  • Han Chinese (Beijing)A;A 17% A;C 40% C;C 43%
  • Japanese (Tokyo)A;A 25% A;C 41% C;C 35%
  • Yoruba (Nigeria)A;A 73% A;C 25% C;C 3%
  • African ancestry (Southwest US)A;A 54% A;C 35% C;C 11%
  • Chinese (Denver)A;A 12% A;C 45% C;C 43%
  • Gujarati IndianA;A 10% A;C 50% C;C 41%
  • Luhya (Kenya)A;A 73% A;C 26% C;C 2%
  • Mexican ancestry (Los Angeles)A;A 14% A;C 52% C;C 35%
  • Maasai (Kenya)A;A 58% A;C 37% C;C 6%
  • TuscanA;A 7% A;C 31% C;C 62%

Conditions, medicines and genes

Other MIA3 SNPs

All MIA3 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

rs17465637 is a SNP found to be associated with heart disease by the German MI (Myocardial infarction) Family Study group This 2011 study concluded that the only MIA3 gene SNP to be associated with increased risk for myocardial infarction is rs17465637, with an odds ratio of 1.17 (CI: 1.04-1.32) and 1.37 (CI: 1.08-1.74) for carriers of one or two (C) alleles, respectively. 23andMe blog coronary artery disease and heart attack SNP Risk Version Effect *rs646776 T 1.19 *rs17465637 C 1.14 *rs1746048 C 1.17 *rs6725887 C 1.17 *rs11206510 T 1.15 *rs3184504 T 1.13 *rs2306374 C 1.15 *rs3782886 C 1.44

Source and license

Adapted from rs17465637 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.