rs2291834

A SNP in the MIA3 gene on chromosome 1. Its most notable genotype is C;C: very slightly higher risk for myocardial infarction

Gene
MIA3
Location
Chr 1222,658,953 (GRCh38)
Highest magnitude
1.1Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
46%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadvery slightly higher risk for myocardial infarctionMinor · 1.129% of people
  2. C;TBadvery slightly higher risk for myocardial infarctionMinor · 1.139% of people
  3. T;TNot ratednormalTypical · 0.032% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 29% C;T 39% T;T 32%
  • European ancestry (Utah)C;C 50% C;T 46% T;T 4%
  • Han Chinese (Beijing)C;C 40% C;T 43% T;T 17%
  • Japanese (Tokyo)C;C 35% C;T 40% T;T 26%
  • Yoruba (Nigeria)C;C 3% C;T 25% T;T 73%
  • African ancestry (Southwest US)C;C 11% C;T 35% T;T 54%
  • Chinese (Denver)C;C 42% C;T 46% T;T 12%
  • Gujarati IndianC;C 37% C;T 51% T;T 13%
  • Luhya (Kenya)C;C 2% C;T 26% T;T 73%
  • Mexican ancestry (Los Angeles)C;C 35% C;T 52% T;T 14%
  • Maasai (Kenya)C;C 6% C;T 37% T;T 58%
  • TuscanC;C 62% C;T 31% T;T 7%

Conditions, medicines and genes

Other MIA3 SNPs

All MIA3 SNPs

Notes

From SNPedia

Notes

rs2291834 is a SNP in the MIA3 gene. Several studies, most notably perhaps by deCode scientists, have shown a (very slightly) elevated risk for myocardial infarctions to be associated with the rs2291834(C) allele.

Source and license

Adapted from rs2291834 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.