rs501120

A SNP on chromosome 10. Its most notable genotype is T;T: common, but >1.3x increased risk for heart disease

Gene
None listed
Location
Chr 1044,258,419 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
28%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadcommon, but >1.3x increased risk for heart diseaseMinor · 1.545% of people
  2. C;TBad1.3x increased risk for heart diseaseMinor · 1.342% of people
  3. G;GNot ratedNo summary available.Typical · 0.00% of people
  4. C;CNot ratednormalTypical · 0.014% of people

SNPedia records rs501120 on the minus strand: (A;A), (A;G), (C;C), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageT;T 45% C;T 42% G;G 0% C;C 14%
  • European ancestry (Utah)T;T 65% C;T 34% G;G 0% C;C 2%
  • Han Chinese (Beijing)T;T 42% C;T 44% G;G 0% C;C 13%
  • Japanese (Tokyo)T;T 43% C;T 41% G;G 0% C;C 16%
  • Yoruba (Nigeria)T;T 29% C;T 48% G;G 0% C;C 24%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 240 words

rs501120 is a SNP found to be associated with heart disease in two populations by the German MI (Myocardial infarction) Family Study group. The risk allele in dbSNP orientation is rs501120(A). The odds ratio per allele is 1.33 (CI: 1.20-1.48, adjusted p=0.0248). Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study. Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration. Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis. Genetics and cardiovascular disease: Design and development of a DNA biobank. Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort. Genetics of coronary artery disease: focus on genome-wide association studies. Genome-wide association studies for atherosclerotic vascular disease and its risk factors. The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts. Association studies of 22 candidate SNPs with late-onset Alzheimer's disease.

Source and license

Adapted from rs501120 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.