rs1010

A SNP in the VAMP8 gene on chromosome 2. Its most notable genotype is C;C: 1.75x risk of MI

Gene
VAMP8
Location
Chr 285,581,859 (GRCh38)
Highest magnitude
1.8Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
45%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TNot ratednormal risk of MITypical · 0.533% of people
  2. C;TBad1.75x risk of MIMinor · 1.046% of people
  3. C;CMost notableBad1.75x risk of MIMinor · 1.822% of people

SNPedia records rs1010 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 33% C;T 46% C;C 22%
  • European ancestry (Utah)T;T 33% C;T 46% C;C 21%
  • Han Chinese (Beijing)T;T 43% C;T 43% C;C 13%
  • Japanese (Tokyo)T;T 34% C;T 50% C;C 17%
  • Yoruba (Nigeria)T;T 15% C;T 52% C;C 33%
  • African ancestry (Southwest US)T;T 30% C;T 37% C;C 33%
  • Chinese (Denver)T;T 48% C;T 39% C;C 13%
  • Gujarati IndianT;T 43% C;T 44% C;C 14%
  • Luhya (Kenya)T;T 19% C;T 52% C;C 29%
  • Mexican ancestry (Los Angeles)T;T 38% C;T 43% C;C 19%
  • Maasai (Kenya)T;T 23% C;T 50% C;C 27%
  • TuscanT;T 35% C;T 47% C;C 18%

Conditions, medicines and genes

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Show notes, about 200 words

This SNP, located on chromosome 2 in a gene (VAMP8) associated with platelet activation, may be associated with early onset myocardial infarction (MI). The risk allele for this SNP (in dbSNP orientation) is rs1010(G), with an odds ratio of 1.75 (CI: 1.17&#226;&#8364;&#8220;2.62). Furthermore, this SNP is one of the 5 used by Celera's genetic risk score (GRS) for coronary heart disease (CHD). *rs20455, in the KIF6 gene *rs3900940, in the MYH15 gene *rs7439293, in the PALLD gene *rs2298566, in the SNX19 gene *rs1010, in the VAMP8 gene For each of the five variants, the GRS was increased by 1 if the subject was homozygous for the risk variant, unchanged if heterozygous, and decreased by 1 if the individual did not carry the variant. Therefore, individuals carrying all 10 possible risk variants (two copies of each of the five SNPs) were assigned a GRS of 5 and those carrying no risk variants a GRS of -5. A high GRS was defined as 3 or higher. Approximately 4% of the white cohort in ARIC was classified as high risk, and the hazard ratio for CHD after adjustment for traditional risk factors was a significant 1.57 (CI: 1.21-2.04; p<0.001). The results did not reproduce for African American participants.

Source and license

Adapted from rs1010 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.