rs2298566

A SNP in the SNX19 gene on chromosome 11. Its most notable genotype is A;C: increased risk of coronary heart disease; better response to statins

Gene
SNX19
Location
Chr 11130,880,747 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
22%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratednormalTypical · 0.04% of people
  2. A;CMost notableNot ratedincreased risk of coronary heart disease; better response to statinsWorth knowing · 2.030% of people
  3. C;CNot ratedincreased risk of coronary heart disease; better response to statinsTypical · 0.066% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 4% A;C 30% C;C 66%
  • European ancestry (Utah)A;A 9% A;C 43% C;C 49%
  • Han Chinese (Beijing)A;A 10% A;C 41% C;C 49%
  • Japanese (Tokyo)A;A 4% A;C 41% C;C 55%
  • Yoruba (Nigeria)A;A 0% A;C 8% C;C 92%
  • African ancestry (Southwest US)A;A 0% A;C 19% C;C 81%
  • Chinese (Denver)A;A 12% A;C 45% C;C 43%
  • Gujarati IndianA;A 2% A;C 21% C;C 77%
  • Luhya (Kenya)A;A 0% A;C 15% C;C 86%
  • Mexican ancestry (Los Angeles)A;A 3% A;C 33% C;C 64%
  • Maasai (Kenya)A;A 1% A;C 18% C;C 81%
  • TuscanA;A 6% A;C 46% C;C 48%

Conditions, medicines and genes

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Show notes, about 170 words

rs2298566 is a SNP in the SNX19 gene. The risk allele in terms of heart disease is rs2298566(C). This SNP is one of the 5 used by Celera's genetic risk score (GRS) for coronary heart disease (CHD). *rs20455, in the KIF6 gene *rs3900940, in the MYH15 gene *rs7439293, in the PALLD gene *rs2298566, in the SNX19 gene *rs1010, in the VAMP8 gene For each of the five variants, the GRS was increased by 1 if the subject was homozygous for the risk variant, unchanged if heterozygous, and decreased by 1 if the individual did not carry the variant. Therefore, individuals carrying all 10 possible risk variants (two copies of each of the five SNPs) were assigned a GRS of 5 and those carrying no risk variants a GRS of -5. A high GRS was defined as 3 or higher. Approximately 4% of the white cohort in ARIC was classified as high risk, and the hazard ratio for CHD after adjustment for traditional risk factors was a significant 1.57 (CI: 1.21-2.04; p<0.001). The results did not reproduce for African American participants.

Source and license

Adapted from rs2298566 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.