rs7439293

A SNP in the PALLD gene on chromosome 4. Its most notable genotype is A;A: increased risk of coronary heart disease; better response to statins

Gene
PALLD
Location
Chr 4168,756,335 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
33%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedincreased risk of coronary heart disease; better response to statinsTypical · 0.09% of people
  2. A;GNot ratedincreased risk of coronary heart disease; better response to statinsTypical · 0.030% of people
  3. G;GNot ratednormalTypical · 0.061% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 9% A;G 30% G;G 61%
  • European ancestry (Utah)A;A 29% A;G 54% G;G 17%
  • Han Chinese (Beijing)A;A 5% A;G 34% G;G 61%
  • Japanese (Tokyo)A;A 2% A;G 25% G;G 73%
  • Yoruba (Nigeria)A;A 0% A;G 8% G;G 92%

Conditions, medicines and genes

Other PALLD SNPs

All PALLD SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Show notes, about 170 words

rs7439293 is a SNP in the PALLD gene. The risk allele in terms of heart disease is rs7439293(A). This SNP is one of the 5 used by Celera's genetic risk score (GRS) for coronary heart disease (CHD). *rs20455, in the KIF6 gene *rs3900940, in the MYH15 gene *rs7439293, in the PALLD gene *rs2298566, in the SNX19 gene *rs1010, in the VAMP8 gene For each of the five variants, the GRS was increased by 1 if the subject was homozygous for the risk variant, unchanged if heterozygous, and decreased by 1 if the individual did not carry the variant. Therefore, individuals carrying all 10 possible risk variants (two copies of each of the five SNPs) were assigned a GRS of 5 and those carrying no risk variants a GRS of -5. A high GRS was defined as 3 or higher. Approximately 4% of the white cohort in ARIC was classified as high risk, and the hazard ratio for CHD after adjustment for traditional risk factors was a significant 1.57 (CI: 1.21-2.04; p<0.001). The results did not reproduce for African American participants.

Source and license

Adapted from rs7439293 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.