rs2943634

A SNP on chromosome 2. Its most notable genotype is A;A: lower risk of ischemic stroke

Gene
None listed
Location
Chr 2226,203,364 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
32%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodlower risk of ischemic strokeWorth knowing · 2.516% of people
  2. C;CBadslightly higher risk of ischemic strokeWorth knowing · 2.549% of people

On SNPedia: (A;A), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 16% C;C 49%
  • European ancestry (Utah)A;A 13% C;C 44%
  • Han Chinese (Beijing)A;A <1% C;C 83%
  • Japanese (Tokyo)A;A 0% C;C 83%
  • Yoruba (Nigeria)A;A 33% C;C 16%
  • African ancestry (Southwest US)A;A 32% C;C 28%
  • Chinese (Denver)A;A 2% C;C 85%
  • Gujarati IndianA;A 2% C;C 63%
  • Luhya (Kenya)A;A 44% C;C 14%
  • Mexican ancestry (Los Angeles)A;A 0% C;C 66%
  • Maasai (Kenya)A;A 39% C;C 15%
  • TuscanA;A 13% C;C 42%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 180 words

rs2943634 is a SNP found to be reproducibly associated with heart disease rs2943634 associated with high density lipoprotein (HDL) cholesterol Association studies of 22 candidate SNPs with late-onset Alzheimer's disease. Evaluation of the association of genetic variants on the chromosomal loci 9p21.3, 6q25.1, and 2q36.3 with angiographically characterized coronary artery disease. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Genome-wide association studies for atherosclerotic vascular disease and its risk factors. Genetics of coronary artery disease: focus on genome-wide association studies. Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort. Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration. Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study.

Source and license

Adapted from rs2943634 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.