rs383830

A SNP on chromosome 5. Its most notable genotype is T;T: 1.9x risk

Gene
None listed
Location
Chr 5100,613,278 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
21%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBad1.9x riskWorth knowing · 2.058% of people
  2. A;TNot rated1.6x riskTypical · 0.035% of people
  3. A;ANot ratednormalTypical · 0.07% of people

SNPedia records rs383830 on the minus strand: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 58% A;T 35% A;A 7%
  • European ancestry (Utah)T;T 62% A;T 35% A;A 4%
  • Han Chinese (Beijing)T;T 66% A;T 31% A;A 4%
  • Japanese (Tokyo)T;T 66% A;T 29% A;A 4%
  • Yoruba (Nigeria)T;T 34% A;T 47% A;A 19%
  • African ancestry (Southwest US)T;T 37% A;T 53% A;A 11%
  • Chinese (Denver)T;T 65% A;T 31% A;A 4%
  • Gujarati IndianT;T 77% A;T 21% A;A 2%
  • Luhya (Kenya)T;T 48% A;T 36% A;A 16%
  • Mexican ancestry (Los Angeles)T;T 72% A;T 26% A;A 2%
  • Maasai (Kenya)T;T 44% A;T 44% A;A 12%
  • TuscanT;T 66% A;T 31% A;A 3%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs383830 has been reported in a large study to be associated with heart disease, in particular, coronary artery disease. The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.60 (CI 1.16-2.21), and for homozygotes, 1.92 (CI 1.40-2.63).

T;T

1.9x higher risk for coronary artery disease

Source and license

Adapted from rs383830 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.