rs174537

A SNP in the MYRF gene on chromosome 11. Its most notable genotype is T;T: lower LDL-C and total cholesterol

Gene
MYRF
Location
Chr 1161,785,208 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
33%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GNot ratedcommon; higher LDL-C and total cholesterolTypical · 0.061% of people
  2. G;TNot ratedcommon; higher LDL-C and total cholesterolTypical · 0.028% of people
  3. T;TMost notableGoodlower LDL-C and total cholesterolWorth knowing · 2.011% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 61% G;T 28% T;T 11%
  • European ancestry (Utah)G;G 43% G;T 44% T;T 12%
  • Han Chinese (Beijing)G;G 40% G;T 45% T;T 15%
  • Japanese (Tokyo)G;G 47% G;T 43% T;T 11%
  • Yoruba (Nigeria)G;G 97% G;T 3% T;T 0%
  • African ancestry (Southwest US)G;G 84% G;T 16% T;T 0%
  • Chinese (Denver)G;G 29% G;T 43% T;T 29%
  • Gujarati IndianG;G 79% G;T 21% T;T 0%
  • Luhya (Kenya)G;G 95% G;T 6% T;T 0%
  • Mexican ancestry (Los Angeles)G;G 12% G;T 45% T;T 43%
  • Maasai (Kenya)G;G 85% G;T 15% T;T <1%
  • TuscanG;G 59% G;T 32% T;T 9%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 260 words

rs174537 is a SNP near the FADS1 gene on chromosome 11. The FADS1 gene is one of 3 fatty acid desaturases in this region; higher polyunsaturated fatty acids (PUFA) levels are generally correlated with lower risk for heart disease. A study of 1,075 participants in the InCHIANTI study on aging concluded that rs174537(T;T) individuals had lower arachidonic acid (AA), as well as lower levels of all other polyunsaturates measured (excepting linoleic acid, which followed the opposite pattern, and alpha-linoleic acid), compared to (G;G) homozgyotes (p = 6 x 10e-46), and that this one SNP accounted for almost 19% of the variance in AA levels. Individuals carrying at least one rs174537(G) allele had higher low-density lipoprotein (LDL-C) and total cholesterol levels. This effect of rs174537 was confirmed in an independent sample of 1,076 participants in the GOLDN study. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Genetic determinants of circulating sphingolipid concentrations in European populations. FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population. Genetic variation in lipid desaturases and its impact on the development of human disease. FADS gene polymorphisms in Koreans: association with omega6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease. Genetics and genomics of human ageing. Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition.

Source and license

Adapted from rs174537 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.