rs7250581

A SNP on chromosome 19. Its most notable genotype is G;G: 1.4x risk

Gene
None listed
Location
Chr 1929,573,489 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
8%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratednormalTypical · 0.0<1% of people
  2. A;GNot ratednormalTypical · 0.07% of people
  3. G;GMost notableBad1.4x riskWorth knowing · 2.092% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 8 HapMap populations.

  • AverageA;A <1% A;G 7% G;G 92%
  • European ancestry (Utah)A;A 2% A;G 29% G;G 69%
  • Han Chinese (Beijing)A;A 0% A;G 0% G;G 100%
  • Japanese (Tokyo)A;A 0% A;G 0% G;G 100%
  • Yoruba (Nigeria)A;A 0% A;G 0% G;G 100%
  • Gujarati IndianA;A 1% A;G 2% G;G 97%
  • Mexican ancestry (Los Angeles)A;A 0% A;G 9% G;G 91%
  • Maasai (Kenya)A;A 0% A;G <1% G;G 99%
  • TuscanA;A 3% A;G 15% G;G 82%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs7250581 has been reported in a large study to be associated with heart disease, in particular, coronary artery disease. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.06 (CI 0.79-1.43), and for homozygotes, 1.40 (CI 1.05-1.86).

G;G

1.4x higher risk for coronary artery disease

Source and license

Adapted from rs7250581 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.