rs5082

A SNP in the APOA2 gene on chromosome 1. Its most notable genotype is G;G: saturated fat contributes to obesity, but 0.57 % lower risk for coronary artery disease

Gene
APOA2
Location
Chr 1161,223,893 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
25%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedsaturated fat contributes to obesity, but 0.57 % lower risk for coronary artery diseaseWorth knowing · 2.55% of people
  2. A;GNot ratednormal riskTypical · 0.031% of people
  3. A;ANot ratednormal riskTypical · 0.064% of people

SNPedia records rs5082 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 5% A;G 31% A;A 64%
  • European ancestry (Utah)G;G 18% A;G 43% A;A 39%
  • Han Chinese (Beijing)G;G 2% A;G 18% A;A 80%
  • Japanese (Tokyo)G;G 0% A;G 8% A;A 92%
  • Yoruba (Nigeria)G;G 5% A;G 42% A;A 54%
  • African ancestry (Southwest US)G;G 4% A;G 46% A;A 51%
  • Chinese (Denver)G;G 0% A;G 17% A;A 84%
  • Gujarati IndianG;G 4% A;G 37% A;A 59%
  • Luhya (Kenya)G;G 3% A;G 19% A;A 78%
  • Mexican ancestry (Los Angeles)G;G 0% A;G 50% A;A 50%
  • Maasai (Kenya)G;G 0% A;G 17% A;A 83%
  • TuscanG;G 17% A;G 45% A;A 38%

Conditions, medicines and genes

Other APOA2 SNPs

All APOA2 SNPs

Notes

From SNPedia

Show notes, about 310 words

rs5082 is a SNP in the apolipoprotein APOA2 gene, and may influence obesity and heart disease risk. Individuals homozygous for the -265T>C polymorphism in rs5082, i.e. individuals with the rs5082(C;C) genotype of the Apolipoprotein A-II gene (APOA2) promoter, are associated with increased Body Mass Index and food intake in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study of ~1000 individuals. The odds ratio for obesity in (C;C) individuals compared to rs5082(T) allele carriers was 1.70 (CI: 1.02-2.80, p=0.039). Total energy, total fat, and total protein intake were all significantly higher in (C;C) individuals. In a separate study, a case-control analysis of 484 Australian male coronary artery disease patients and 498 male controls concluded that rs5082(C;C) individuals were at significantly lower risk for that form of heart disease than rs5082(T) allele carriers (odds ratio 0.57, CI: 0.39-0.84, p=0.004). A meta-analysis of several APOA2 SNPs (including this one) found no association between any APOA2 SNPs studied and type-2 diabetes. An apolipoprotein A-II polymorphism (-265T/C, rs5082) regulates postprandial response to a saturated fat overload in healthy men. No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins. Response to Diet and Exercise

G;G

PMID 17446329 rs5082(C;C) associated with increased Body Mass Index and food intake in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study. PMID 18179799 rs5082(C;C) associated with significantly decreased risk of coronary heart diesease in an Australian male population news Tufts University scientists said they discovered men and women carrying the CC genotype demonstrated higher body mass index scores and a higher incidence of obesity, but only if they consumed a diet high in saturated fat.

References

Source and license

Adapted from rs5082 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.