rs6922269

A SNP in the MTHFD1L gene on chromosome 6. Its most notable genotype is A;A: 1.6x risk of coronary artery disease

Gene
MTHFD1L
Location
Chr 6150,931,849 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
29%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad1.6x risk of coronary artery diseaseWorth knowing · 2.017% of people
  2. A;GBad1.2x risk of coronary artery diseaseTypical · 0.033% of people
  3. G;GNot ratednormalTypical · 0.050% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 9 HapMap populations.

  • AverageA;A 17% A;G 33% G;G 50%
  • European ancestry (Utah)A;A 8% A;G 37% G;G 55%
  • Han Chinese (Beijing)A;A 0% A;G 4% G;G 96%
  • Japanese (Tokyo)A;A 0% A;G 2% G;G 98%
  • Yoruba (Nigeria)A;A 46% A;G 42% G;G 12%
  • African ancestry (Southwest US)A;A 35% A;G 44% G;G 21%
  • Gujarati IndianA;A 6% A;G 43% G;G 51%
  • Luhya (Kenya)A;A 37% A;G 48% G;G 16%
  • Mexican ancestry (Los Angeles)A;A 11% A;G 42% G;G 47%
  • TuscanA;A 11% A;G 33% G;G 56%

Conditions, medicines and genes

Other MTHFD1L SNPs

All MTHFD1L SNPs

Notes

From SNPedia

Notes

rs6922269 has been reported in a large study to be associated with heart disease, in particular, coronary artery disease. The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.17 (CI 1.04-1.32), and for homozygotes, 1.65 (CI 1.32-2.06).

G;G

Normal/average risk for heart disease

Source and license

Adapted from rs6922269 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.