rs5918

A SNP in the ITGB3 gene on chromosome 17. Its most notable genotype is C;C: MI risk, aspirin resistance

Gene
ITGB3
Location
Chr 1747,283,364 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
9%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadMI risk, aspirin resistanceWorth knowing · 2.52% of people
  2. C;TBadMI risk, aspirin resistanceWorth knowing · 2.016% of people
  3. T;TGoodaverageTypical · 0.082% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 2% C;T 16% T;T 82%
  • European ancestry (Utah)C;C 2% C;T 24% T;T 74%
  • Han Chinese (Beijing)C;C 0% C;T 2% T;T 99%
  • Japanese (Tokyo)C;C 0% C;T 2% T;T 98%
  • Yoruba (Nigeria)C;C 2% C;T 21% T;T 77%
  • African ancestry (Southwest US)C;C 5% C;T 14% T;T 81%
  • Chinese (Denver)C;C 0% C;T <1% T;T 99%
  • Gujarati IndianC;C 1% C;T 16% T;T 83%
  • Luhya (Kenya)C;C 3% C;T 24% T;T 74%
  • Mexican ancestry (Los Angeles)C;C 2% C;T 19% T;T 79%
  • Maasai (Kenya)C;C 3% C;T 28% T;T 69%
  • TuscanC;C 4% C;T 25% T;T 72%

Conditions, medicines and genes

Other ITGB3 SNPs

All ITGB3 SNPs

Notes

From SNPedia

Show notes, about 220 words

The 'A2' allele of the platelet specific alloantigen system is encoded by rs5918(C), and it has been implicated as increasing the risk of myocardial infarction, heart disease, and resistance to blood-thinning benefits of aspirin. On its own, the A2 allele is implicated especially in early onset heart disease ; in combination with the 4G allele of the PAI1 gene, rs1799889, the increased risk of myocardial infarction in a Finnish study population was 4 fold higher (odds ratio = 4.5, p=0.001), particularly in males (odds ratio = 6.4, p=0.0005) . Olympic skater Sergei Grinkov, who had this risk factor, died of a heart attack at age 28. esgweb1.nts.jhu.edu A2 allele carriers also appear to be relatively resistant to the anti-thrombotic (i.e. anti-clotting) actions normally associated with aspirin use. A protective effect of rs5918 has also been observed for the development of Non-Hodgkin Lymphoma, both for the SNP (which is also known as L59P) and for its gene, ITGB3. The odds ratio is 0.66 (CI: 0.52-0.85). rs5918 is not associated with breast cancer risk for either BRCA1 or BRCA2 mutation carriers, based on a multi-center study including ~10,000 patients from 34 studies.

C;C

23andMe blog lower odds of early stent thrombosis

C;T

23andMe blog lower odds of early stent thrombosis

Source and license

Adapted from rs5918 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.