rs3900940
A SNP in the MYH15 gene on chromosome 3. Its most notable genotype is C;C: slightly increased risk of coronary heart disease
- Gene
- MYH15
- Location
- Chr 3108,428,881 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, FamilyTreeDNA
- Minor allele frequency
- 18%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableNot ratedslightly increased risk of coronary heart disease
- C;TNot ratedslightly increased risk of coronary heart disease
- T;TNot ratednormal
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 3% C;T 23% T;T 74%
- European ancestry (Utah)C;C 9% C;T 47% T;T 44%
- Han Chinese (Beijing)C;C 0% C;T 0% T;T 100%
- Japanese (Tokyo)C;C 0% C;T 0% T;T 100%
- Yoruba (Nigeria)C;C 2% C;T 29% T;T 69%
- African ancestry (Southwest US)C;C 0% C;T 33% T;T 67%
- Chinese (Denver)C;C 0% C;T <1% T;T 99%
- Gujarati IndianC;C 3% C;T 28% T;T 69%
- Luhya (Kenya)C;C 0% C;T 16% T;T 84%
- Mexican ancestry (Los Angeles)C;C 7% C;T 31% T;T 62%
- Maasai (Kenya)C;C 3% C;T 28% T;T 69%
- TuscanC;C 13% C;T 38% T;T 49%
Related
Conditions, medicines and genes
Genosets
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Show notes, about 170 words
rs3900940 is a SNP in the MYH15 gene. The risk allele in terms of heart disease is rs3900940(C). This SNP is one of the 5 used by Celera's genetic risk score (GRS) for coronary heart disease (CHD). *rs20455, in the KIF6 gene *rs3900940, in the MYH15 gene *rs7439293, in the PALLD gene *rs2298566, in the SNX19 gene *rs1010, in the VAMP8 gene For each of the five variants, the GRS was increased by 1 if the subject was homozygous for the risk variant, unchanged if heterozygous, and decreased by 1 if the individual did not carry the variant. Therefore, individuals carrying all 10 possible risk variants (two copies of each of the five SNPs) were assigned a GRS of 5 and those carrying no risk variants a GRS of -5. A high GRS was defined as 3 or higher. Approximately 4% of the white cohort in ARIC was classified as high risk, and the hazard ratio for CHD after adjustment for traditional risk factors was a significant 1.57 (CI: 1.21-2.04; p<0.001). The results did not reproduce for African American participants.
Source and license
Adapted from rs3900940 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.