rs8055236

A SNP in the CDH13 gene on chromosome 16. Its most notable genotype is G;G: common, but 2.2x higher risk for heart disease

Gene
CDH13
Location
Chr 1683,178,793 (GRCh38)
Highest magnitude
1.7Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
24%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratedNo summary available.Typical · 0.00% of people
  2. G;GMost notableBadcommon, but 2.2x higher risk for heart diseaseMinor · 1.752% of people
  3. G;TBad1.9x risk for heart diseaseMinor · 1.735% of people
  4. T;TNot ratednormalTypical · 0.013% of people

On SNPedia: (A;A), (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 0% G;G 52% G;T 35% T;T 13%
  • European ancestry (Utah)A;A 0% G;G 64% G;T 34% T;T 3%
  • Han Chinese (Beijing)A;A 0% G;G 76% G;T 23% T;T 2%
  • Japanese (Tokyo)A;A 0% G;G 72% G;T 27% T;T <1%
  • Yoruba (Nigeria)A;A 0% G;G 19% G;T 47% T;T 34%
  • African ancestry (Southwest US)A;A 0% G;G 25% G;T 46% T;T 30%
  • Chinese (Denver)A;A 0% G;G 82% G;T 16% T;T 2%
  • Gujarati IndianA;A 0% G;G 66% G;T 30% T;T 4%
  • Luhya (Kenya)A;A 0% G;G 18% G;T 50% T;T 32%
  • Mexican ancestry (Los Angeles)A;A 0% G;G 74% G;T 26% T;T 0%
  • Maasai (Kenya)A;A 0% G;G 16% G;T 58% T;T 26%
  • TuscanA;A 0% G;G 62% G;T 32% T;T 6%

Conditions, medicines and genes

Other CDH13 SNPs

All CDH13 SNPs

Notes

From SNPedia

Notes

rs8055236 has been reported in a large study to be associated with heart disease, in particular, coronary artery disease. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.91 (CI 1.33-2.74), and for homozygotes, 2.23 (CI 1.56-3.17).

Source and license

Adapted from rs8055236 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.