rs9574

A SNP in the PROCR gene on chromosome 20. Its most notable genotype is C;C: EPCR H1 diplotype; reduced risk of VTE?

Gene
PROCR
Location
Chr 2035,176,829 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
45%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedEPCR H1 diplotype; reduced risk of VTE?Typical · 0.029% of people
  2. C;GNot ratedEPCR H1 haplotype; reduced risk of VTE?Typical · 0.037% of people
  3. G;GNot ratednormal risk for VTETypical · 0.034% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 29% C;G 37% G;G 34%
  • European ancestry (Utah)C;C 22% C;G 43% G;G 35%
  • Han Chinese (Beijing)C;C 36% C;G 44% G;G 20%
  • Japanese (Tokyo)C;C 52% C;G 41% G;G 7%
  • Yoruba (Nigeria)C;C 7% C;G 21% G;G 73%

Conditions, medicines and genes

Other PROCR SNPs

All PROCR SNPs

Notes

From SNPedia

Notes

rs9574 is a SNP that can indicate haplotype H1 of the PROCR gene. The protein product of the PROCR gene activates a part of the anticoagulation pathway. While the rs9574(G) allele could indicate haplotypes H2, H3 or H4, the rs9574(C) allele distinctly tags (identifies) the H1 haplotype. The H1 haplotype (and thus rs9574(C)) has been reported to be associated with a reduced risk of venous thromboembolism (VTE), with an odds ratio of 0.59, CI: 0.41–0.84. Two other groups have not found this association to be statistically valid in the populations they studied.PMID 14576048, PMID 15304035

Source and license

Adapted from rs9574 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.