rs867186

A SNP in the PROCR gene on chromosome 20. Its most notable genotype is A;A: normal risk for VTE

Gene
PROCR
Location
Chr 2035,176,751 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
8%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormal risk for VTETypical · 0.083% of people
  2. A;GNot ratedEPCR H3 haplotype; reduced or increased risk of VTE?Typical · 0.016% of people
  3. G;GNot ratedEPCR H3 diplotype; reduced or increased risk of VTE?Typical · 0.0<1% of people
  4. T;TNot ratedNo summary available.Typical · 0.00% of people

On SNPedia: (A;A), (A;G), (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 83% A;G 16% G;G <1% T;T 0%
  • European ancestry (Utah)A;A 81% A;G 18% G;G <1% T;T 0%
  • Han Chinese (Beijing)A;A 92% A;G 8% G;G 0% T;T 0%
  • Japanese (Tokyo)A;A 89% A;G 12% G;G 0% T;T 0%
  • Yoruba (Nigeria)A;A 85% A;G 15% G;G 0% T;T 0%
  • African ancestry (Southwest US)A;A 86% A;G 14% G;G 0% T;T 0%
  • Chinese (Denver)A;A 82% A;G 17% G;G <1% T;T 0%
  • Gujarati IndianA;A 72% A;G 27% G;G 1% T;T 0%
  • Luhya (Kenya)A;A 80% A;G 18% G;G 2% T;T 0%
  • Mexican ancestry (Los Angeles)A;A 86% A;G 12% G;G 2% T;T 0%
  • Maasai (Kenya)A;A 81% A;G 19% G;G 0% T;T 0%
  • TuscanA;A 80% A;G 19% G;G 1% T;T 0%

Conditions, medicines and genes

Other PROCR SNPs

All PROCR SNPs

Notes

From SNPedia

Show notes, about 130 words

rs867186 is a SNP that can indicate haplotype H3 of the EPCR gene. The protein product of the EPCR gene activates a part of the anticoagulation pathway. While the rs867186(A) allele could indicate haplotypes H1, H2 or H4, the rs867186(G) allele distinctly tags (identifies) the H3 haplotype. While most groups studying EPCR H3 agree that it leads to increased soluble EPCR, and thus should theoretically lead to reduced risk for venous thromboembolism, different groups come to different conclusions about the effect in the populations each studies. Two find no association PMID 15304035, PMID 15116250 while one finds that the H3 haplotype (and thus rs867186(G)) actually increases the risk of venous thromboembolism (VTE), with an odds ratio of 1.80, p=0.004.

Source and license

Adapted from rs867186 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.