rs138925964
A SNP in the PROS1 gene on chromosome 3. Its most notable genotype is T;T: Clotting issues likely in infants
- Gene
- PROS1
- Location
- Chr 393,879,279 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon/normal
- C;TBad2-4x higher risk for venous thromboembolism (clots)
- T;TMost notableBadClotting issues likely in infants
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other PROS1 SNPs
- rs387906675C;CProtein-S deficiency; severeVery important
- rs121918472G;GIncreased venous thromboembolism risk (> 6x)Very important
- rs6122A;GPartial protein-S deficiency; higher risk for blood clotting related issuesVery important
- rs121918473C;TPartial protein-S deficiency; higher risk for blood clotting related issuesVery important
- rs121918474C;TPartial protein-S deficiency; higher risk for blood clotting related issuesVery important
- rs121918475A;GPartial protein-S deficiency; higher risk for blood clotting related issuesVery important
- rs121918476C;GPartial protein-S deficiency; higher risk for blood clotting related issuesVery important
- rs267606981A;TPartial protein-S deficiency; higher risk for blood clotting related issuesVery important
Notes
From SNPedia
Notes
rs138925964, also known as c.1528G>A, p.Val510Met and V510M, represents a fairly rare mutation in the PROS1 gene on chromosome 3. Based on exome sequencing, a 2016 report concludes that the rs138925964(T) allele is an African-descent specific risk factor for venous thromboembolism, also known as VTE. Individuals carrying this allele are reported to be at 2 - 4 fold higher VTE risk. A news report about this finding and other ancestry-specific risk factors is here.
C;T
see discussion at rs138925964
T;T
see discussion at rs138925964
Source and license
Adapted from rs138925964 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.