rs387906675
A SNP in the PROS1 gene on chromosome 3. Its most notable genotype is C;C: Protein-S deficiency; severe
- Gene
- PROS1
- Location
- Chr 393,900,830 (GRCh38)
- Highest magnitude
- 9.0Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TGoodcommon in clinvar
- C;TBadCarrier of a protein-S deficiency mutation
- C;CMost notableBadProtein-S deficiency; severe
SNPedia records rs387906675 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other PROS1 SNPs
- rs121918472G;GIncreased venous thromboembolism risk (> 6x)Very important
- rs138925964T;TClotting issues likely in infantsVery important
- rs6122A;GPartial protein-S deficiency; higher risk for blood clotting related issuesVery important
- rs121918473C;TPartial protein-S deficiency; higher risk for blood clotting related issuesVery important
- rs121918474C;TPartial protein-S deficiency; higher risk for blood clotting related issuesVery important
- rs121918475A;GPartial protein-S deficiency; higher risk for blood clotting related issuesVery important
- rs121918476C;GPartial protein-S deficiency; higher risk for blood clotting related issuesVery important
- rs267606981A;TPartial protein-S deficiency; higher risk for blood clotting related issuesVery important
Notes
From SNPedia
Notes
aka c.701A>G (p.Tyr234Cys)
C;T
Unaffected in absence of a second PROS1 gene mutation (?)
C;C
See discussion via OMIM links from main rs-page
Source and license
Adapted from rs387906675 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.