rs5361

A SNP in the SELE gene on chromosome 1. Its most notable genotype is G;G: 4x increased risk for recurrent venous thromboembolism.

Gene
SELE
Location
Chr 1169,731,919 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
6%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TGoodnormal riskTypical · 0.090% of people
  2. G;TNot ratednormal riskTypical · 0.09% of people
  3. G;GMost notableBad4x increased risk for recurrent venous thromboembolism.Worth knowing · 2.5<1% of people

SNPedia records rs5361 on the minus strand: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 90% G;T 9% G;G <1%
  • European ancestry (Utah)T;T 78% G;T 20% G;G 2%
  • Han Chinese (Beijing)T;T 99% G;T 2% G;G 0%
  • Japanese (Tokyo)T;T 96% G;T 4% G;G 0%
  • Yoruba (Nigeria)T;T 96% G;T 4% G;G 0%
  • African ancestry (Southwest US)T;T 84% G;T 14% G;G 2%
  • Chinese (Denver)T;T 97% G;T 3% G;G 0%
  • Gujarati IndianT;T 81% G;T 17% G;G 2%
  • Luhya (Kenya)T;T 96% G;T 5% G;G 0%
  • Mexican ancestry (Los Angeles)T;T 90% G;T 10% G;G 0%
  • Maasai (Kenya)T;T 98% G;T 2% G;G 0%
  • TuscanT;T 79% G;T 21% G;G 0%

Conditions, medicines and genes

Other SELE SNPs

All SELE SNPs

Notes

From SNPedia

Notes

The rs5361 Ser128Arg variation in this gene, known as E-selectin, is linked to several thrombotic disorders. rs5361(C;C) homozygous carriers of the Ser128Arg allele are at a 4X higher risk for recurrent venous thromboembolism (VTE); heterozygous carriers are not at increased risk. .

G;G

rs5361(C;C) homozygous carriers of the Ser128Arg allele are at a 4X higher risk for recurrent venous thromboembolism (VTE); heterozygous carriers are not at increased risk. PMID 16908800.

References

Source and license

Adapted from rs5361 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.