i3002758
A SNP in the TTR gene on chromosome 18. Its most notable genotype is A;A: TTR-related Familial Amyloid Polyneuropathy
- Gene
- TTR
- Location
- Chr 1829,172,937 (GRCh38)
- Highest magnitude
- 4.0Very important
- Tested on
- 23andMe
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadTTR-related Familial Amyloid Polyneuropathy
- A;GBadTTR-related Familial Amyloid Polyneuropathy
- G;GGoodNormal
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other TTR SNPs
- rs11541790C;TTTR-related amyloidosisVery important
- rs11541796A;GTTR-related amyloidosisVery important
- rs28933979A;GTTR-related amyloidosisVery important
- rs76992529A;GTTR-related amyloidosisVery important
- rs79977247C;TTTR-related amyloidosisVery important
- rs104894664A;GTTR-related amyloidosisVery important
- rs104894665C;TTTR-related amyloidosisVery important
- rs121918068A;TTTR-related amyloidosisVery important
Notes
From SNPedia
Notes
TTR-Related Familial Amyloid Polyneuropathy Familial amyloid polyneuropathies are neurological conditions. https://www.23andme.com/you/journal/ttr_familial_amyloid_polyneuropathy/techreport/ rs28933979
A;A
The majority of people with this genotype develop the neurological condition known as TTR-related familial amyloid polyneuropathy by the time they are 80, although the age of onset varies.
A;G
The majority of people with this genotype develop the neurological condition known as TTR-related familial amyloid polyneuropathy by the time they are 80, although the age of onset varies.
Source and license
Adapted from i3002758 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.