i4000309
A SNP in the CFTR gene on chromosome 7. Its most notable genotype is A;A: Cystic Fibrosis
- Gene
- CFTR
- Location
- Chr 7117,282,620 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- 23andMe
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadCystic Fibrosis
- A;GBadCystic Fibrosis carrier
- G;GGoodnormal
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other CFTR SNPs
- i4000292D;Dcystic fibrosisVery important
- rs74551128A;ACystic fibrosisVery important
- rs113993960-;-Cystic Fibrosis; homozygote for delta F-508 mutationVery important
- rs199826652-;-Cystic Fibrosis; homozygote for delta F-508 mutationVery important
- i4000294A;ACystic FibrosisVery important
- i4000296T;TCystic FibrosisVery important
- i4000297A;ACystic FibrosisVery important
- i4000299T;TCystic FibrosisVery important
Notes
From SNPedia
Notes
Cystic Fibrosis rs77010898
A;A
Also known as W1282X seems to be less common. Any known carrier issues? https://www.23andme.com/you/community/thread/4015/
A;G
Also known as W1282X seems to be less common cause of Cystic Fibrosis. Any known carrier issues? https://www.23andme.com/you/community/thread/4015/
Source and license
Adapted from i4000309 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.