i4000462
A SNP in the CHEK2 gene on chromosome 22. Its most notable genotype is D;I: increased risk of breast and prostate cancer
- Gene
- CHEK2
- Location
- Chr 2229,091,857 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- 23andMe
Genotypes
As shown in 23andMe and AncestryDNA files.
- D;IMost notableBadincreased risk of breast and prostate cancer
- I;IGoodcommon/normal
On SNPedia: (D;I), (I;I). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other CHEK2 SNPs
- rs121908702A;CBreast cancer associated mutationVery important
- rs137853007A;GBreast cancer associated mutationVery important
- rs587780183-;ABreast cancer associated mutationVery important
- rs587780184-;ABreast cancer associated mutationVery important
- rs587780186-;CBreast cancer associated mutationVery important
- rs587781269A;GBreast cancer associated mutationVery important
- rs587781592A;GBreast cancer associated mutationVery important
- rs587781699C;TBreast cancer associated mutationVery important
Notes
From SNPedia
Notes
Breast Cancer rs555607708
D;I
2 to 5 fold increase in risk for breast and/or prostate cancer, especially in families prone to either
Source and license
Adapted from i4000462 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.