i4000488
A SNP in the PALB2 gene on chromosome 16. Its most notable genotype is D;I: 3 to 5 fold increase in relative risk for breast cancer
- Gene
- PALB2
- Location
- Chr 1623,646,275 (GRCh38)
- Highest magnitude
- 4.0Very important
- Tested on
- 23andMe
Genotypes
As shown in 23andMe and AncestryDNA files.
- D;IMost notableBad3 to 5 fold increase in relative risk for breast cancer
- I;IGoodcommon/normal
On SNPedia: (D;I), (I;I). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other PALB2 SNPs
- rs118203997T;TFanconi anemia, complementation group NVery important
- rs118203998C;CFanconi anemia, complementation group NVery important
- rs118203999A;AFanconi anemia, complementation group NVery important
- rs180177083A;AFanconi anemia, complementation group NVery important
- rs180177084-;-Fanconi anemia, complementation group NVery important
- rs180177085-;-Fanconi anemia, complementation group NVery important
- rs180177090-;-Fanconi anemia, complementation group NVery important
- rs180177091A;AFanconi anemia, complementation group NVery important
Notes
From SNPedia
Notes
see discussion at rs180177102 breast cancer
D;I
see discussion at rs180177102; this genotype is the equivalent of rs180177102(-;T)
I;I
see discussion at rs180177102; this genotype is the equivalent of rs180177102(T;T)
Source and license
Adapted from i4000488 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.