rs1000113

A SNP in the IRGM gene on chromosome 5. Its most notable genotype is C;C: normal

Gene
IRGM
Location
Chr 5150,860,514 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
21%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodnormalTypical · 0.061% of people
  2. C;TBad1.5x risk of Crohn's diseaseTypical · 0.033% of people
  3. T;TBad1.9x risk of Crohn's diseaseTypical · 0.06% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 61% C;T 33% T;T 6%
  • European ancestry (Utah)C;C 91% C;T 9% T;T 0%
  • Han Chinese (Beijing)C;C 39% C;T 48% T;T 13%
  • Japanese (Tokyo)C;C 44% C;T 41% T;T 15%
  • Yoruba (Nigeria)C;C 52% C;T 46% T;T 3%
  • African ancestry (Southwest US)C;C 58% C;T 39% T;T 4%
  • Chinese (Denver)C;C 29% C;T 53% T;T 17%
  • Gujarati IndianC;C 88% C;T 11% T;T 1%
  • Luhya (Kenya)C;C 67% C;T 32% T;T <1%
  • Mexican ancestry (Los Angeles)C;C 69% C;T 26% T;T 5%
  • Maasai (Kenya)C;C 63% C;T 32% T;T 5%
  • TuscanC;C 72% C;T 28% T;T 1%

Conditions, medicines and genes

Other IRGM SNPs

All IRGM SNPs

Notes

From SNPedia

Notes

rs1000113 has been reported in a large study to be associated with Crohn's disease. The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 1.54 (CI 1.31-1.82), and for homozygotes, 1.92 (CI 0.92-4.00).

Source and license

Adapted from rs1000113 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.