rs10065172
A SNP in the IRGM gene on chromosome 5. Its most notable genotype is C;C: common in complete genomics
- Gene
- IRGM
- Location
- Chr 5150,848,436 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 28%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageC;C 49%
- European ancestry (Utah)C;C 95%
- Han Chinese (Beijing)C;C 33%
- Japanese (Tokyo)C;C 42%
- Yoruba (Nigeria)C;C 25%
Related
Conditions, medicines and genes
Notes
From SNPedia
Notes
blog summary of says :The exonic SNP c.313C>T (rs10065172) is in perfect linkage disequilibrium (r2=1.0) with a deletion polymorphism of 20 kbp mapping upstream of the IRGM gene. This deletion has been strongly associated with Crohn's disease in several European populations or those with European ancestry.
Source and license
Adapted from rs10065172 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.