rs1006737

A SNP in the CACNA1C gene on chromosome 12. Its most notable genotype is A;A: increased risk of Bipolar disorder

Gene
CACNA1C
Location
Chr 122,236,129 (GRCh38)
Highest magnitude
1.7Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
30%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedincreased risk of Bipolar disorderMinor · 1.713% of people
  2. G;GNot ratedNo summary available.Typical · 0.051% of people

On SNPedia: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 13% G;G 51%
  • European ancestry (Utah)A;A 13% G;G 44%
  • Han Chinese (Beijing)A;A 2% G;G 88%
  • Japanese (Tokyo)A;A 0% G;G 88%
  • Yoruba (Nigeria)A;A 38% G;G 19%
  • African ancestry (Southwest US)A;A 26% G;G 21%
  • Chinese (Denver)A;A 0% G;G 89%
  • Gujarati IndianA;A 5% G;G 51%
  • Luhya (Kenya)A;A 31% G;G 17%
  • Mexican ancestry (Los Angeles)A;A 9% G;G 49%
  • Maasai (Kenya)A;A 8% G;G 39%
  • TuscanA;A 6% G;G 57%

Conditions, medicines and genes

Other CACNA1C SNPs

All CACNA1C SNPs

Notes

From SNPedia

Notes

During perception of fearful faces, the presence of the A risk allele was associated with decreased outflow of information from medial frontal gyrus (MFG), which was significantly more marked in patients than in their unaffected relatives and healthy controls.

Source and license

Adapted from rs1006737 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.