rs2159100

A SNP in the CACNA1C gene on chromosome 12. Its most notable genotype is C;C: common/normal

Gene
CACNA1C
Location
Chr 122,237,227 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
31%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommon/normalTypical · 0.051% of people
  2. C;TBadNo summary available.Typical · 0.036% of people
  3. T;TBad2.36 increased odds of bipolar disorderTypical · 0.013% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 51% C;T 36% T;T 13%
  • European ancestry (Utah)C;C 43% C;T 43% T;T 13%
  • Han Chinese (Beijing)C;C 88% C;T 10% T;T 2%
  • Japanese (Tokyo)C;C 88% C;T 12% T;T 0%
  • Yoruba (Nigeria)C;C 18% C;T 43% T;T 39%
  • African ancestry (Southwest US)C;C 21% C;T 53% T;T 26%
  • Chinese (Denver)C;C 90% C;T 10% T;T 0%
  • Gujarati IndianC;C 52% C;T 44% T;T 5%
  • Luhya (Kenya)C;C 17% C;T 51% T;T 32%
  • Mexican ancestry (Los Angeles)C;C 48% C;T 41% T;T 10%
  • Maasai (Kenya)C;C 39% C;T 53% T;T 8%
  • TuscanC;C 57% C;T 37% T;T 6%

Conditions, medicines and genes

Other CACNA1C SNPs

All CACNA1C SNPs

Notes

From SNPedia

Notes

23andMe blog () rs1006737 or (rs2159100) Each T at this SNP increased the odds of bipolar disorder by 1.18 times compared to having two CC copies This study finds evidence for rs2159100 allele T as a factor in schizophrenia.

C;T

1.18 increased odds of bipolar disorder

Source and license

Adapted from rs2159100 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.