rs10239794

A SNP in the DPP6 gene on chromosome 7. Its most notable genotype is C;C: Probably benign; one 2008 study reports 1.3x higher risk for ALS

Gene
DPP6
Location
Chr 7154,508,809 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
46%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedProbably benign; one 2008 study reports 1.3x higher risk for ALSMinor · 1.019% of people
  2. C;TNot ratedProbably benign; only one 2008 study reports 1.3x higher risk for ALSMinor · 1.051% of people
  3. T;TGoodcommon/normalTypical · 0.030% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 19% C;T 51% T;T 30%
  • European ancestry (Utah)C;C 41% C;T 43% T;T 17%
  • Han Chinese (Beijing)C;C 7% C;T 53% T;T 40%
  • Japanese (Tokyo)C;C 4% C;T 37% T;T 60%
  • Yoruba (Nigeria)C;C 20% C;T 55% T;T 25%
  • African ancestry (Southwest US)C;C 12% C;T 53% T;T 35%
  • Chinese (Denver)C;C 12% C;T 42% T;T 46%
  • Gujarati IndianC;C 27% C;T 55% T;T 19%
  • Luhya (Kenya)C;C 18% C;T 62% T;T 20%
  • Mexican ancestry (Los Angeles)C;C 26% C;T 57% T;T 17%
  • Maasai (Kenya)C;C 13% C;T 55% T;T 32%
  • TuscanC;C 31% C;T 54% T;T 15%

Other DPP6 SNPs

All DPP6 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Show notes, about 120 words

rs10239794, a SNP in the region of the DPP6 gene on chromosome 7, has been associated with the sporadic form of ALS (Lou Gehrig's disease) in a 2008 study of 1000+ European patients. The odds ratio for the risk allele rs10239794(C) is 1.30 (CI: 1.18 - 1.43). A "CC" haplotype for this SNP and that of it's neighbor rs10260404 is also highly (statistically; p=10e-9) associated with ALS. However, a subsequent publication was unable to replicate the association with rs10260404, and to our knowledge, in the years since 2008 there has not been a report replicating the association of rs10239794 with ALS.

C;C

Note minor allele is very common in most populations

C;T

Note minor allele is very common in most populations

Source and license

Adapted from rs10239794 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.