rs10260404

A SNP in the DPP6 gene on chromosome 7. Its most notable genotype is C;C: 1.60x risk of developing ALS

Gene
DPP6
Location
Chr 7154,513,713 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
29%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad1.60x risk of developing ALSWorth knowing · 2.09% of people
  2. C;TBad1.20x risk of developing ALSMinor · 1.540% of people
  3. T;TGoodNormal risk of developing ALSMinor · 1.051% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 9% C;T 40% T;T 51%
  • European ancestry (Utah)C;C 20% C;T 49% T;T 32%
  • Han Chinese (Beijing)C;C 3% C;T 35% T;T 62%
  • Japanese (Tokyo)C;C 0% C;T 27% T;T 73%
  • Yoruba (Nigeria)C;C 10% C;T 45% T;T 46%
  • African ancestry (Southwest US)C;C 9% C;T 33% T;T 58%
  • Chinese (Denver)C;C 3% C;T 32% T;T 65%
  • Gujarati IndianC;C 15% C;T 48% T;T 38%
  • Luhya (Kenya)C;C 11% C;T 45% T;T 45%
  • Mexican ancestry (Los Angeles)C;C 9% C;T 47% T;T 45%
  • Maasai (Kenya)C;C 6% C;T 30% T;T 64%
  • TuscanC;C 18% C;T 49% T;T 34%

Other DPP6 SNPs

All DPP6 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Show notes, about 130 words

rs10260404, a SNP in the region of the DPP6 gene on chromosome 7, has been associated with the sporadic form of ALS (Lou Gehrig's disease) in a study of 1000+ European patients. The overall odds ratio for the risk allele rs10260404(C) is 1.30 (CI: 1.18-1.43, p=0.017). When broken down by genotype, the odds ratios for heterozygotes are 1.20 (CI: 1.06-1.41), and for rs10260404(C;C) homozygotes, 1.60 (CI: 1.32-1.92). A "C-C" haplotype for this SNP and that of it's neighbor rs10239794 is also highly (statistically; p=10e-9) associated with ALS. However, in an expanded study pooling 4 populations (Irish, Dutch, US, Polish) rs10260404 failed to reach Bonferroni significance. although it did remain significant in the (expanded) Irish-only population.

Source and license

Adapted from rs10260404 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.