rs1034428

A SNP in the GRIA3 gene on chromosome X. Its most notable genotype is G;G: common/normal

Gene
GRIA3
Location
Chr X123,303,197 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
16%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommon/normalTypical · 0.084% of people
  2. A;GNot rated2.19x increased risk for schizophrenia in femalesTypical · 0.011% of people
  3. A;ANot rated2.19x increased risk for schizophrenia in femalesTypical · 0.04% of people

SNPedia records rs1034428 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 84% A;G 11% A;A 4%
  • European ancestry (Utah)G;G 71% A;G 22% A;A 8%
  • Han Chinese (Beijing)G;G 96% A;G 4% A;A 0%
  • Japanese (Tokyo)G;G 93% A;G 5% A;A 2%
  • Yoruba (Nigeria)G;G 78% A;G 14% A;A 8%

Conditions, medicines and genes

Other GRIA3 SNPs

All GRIA3 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

Female carriers of an rs1034428(T) allele (as oriented in dbSNP) have a 2.19x higher risk for schizophrenia compared to non-carriers, and a 3.28x higher risk for a non-paranoid phenotype. This SNP is part of a specific haplotype, rs989638-rs1034428-rs2227098 G-T-G (as oriented with respect to dbSNP) with an overall ~2x higher risk in females for schizophrenia (p=0.0008).

Source and license

Adapted from rs1034428 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.