rs4825476

A SNP in the GRIA3 gene on chromosome X. Its most notable genotype is G;G: 1.9x higher risk of suicidal thoughts when taking citalopram

Gene
GRIA3
Location
Chr X123,307,628 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
34%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratednormalTypical · 0.053% of people
  2. A;GNot ratednormalTypical · 0.022% of people
  3. G;GMost notableBad1.9x higher risk of suicidal thoughts when taking citalopramWorth knowing · 2.025% of people
  4. T;TNot ratedNo summary available.Typical · 0.00% of people

On SNPedia: (A;A), (A;G), (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 53% A;G 22% G;G 25% T;T 0%
  • European ancestry (Utah)A;A 66% A;G 19% G;G 16% T;T 0%
  • Han Chinese (Beijing)A;A 44% A;G 29% G;G 27% T;T 0%
  • Japanese (Tokyo)A;A 50% A;G 27% G;G 24% T;T 0%
  • Yoruba (Nigeria)A;A 49% A;G 25% G;G 26% T;T 0%
  • African ancestry (Southwest US)A;A 46% A;G 28% G;G 26% T;T 0%
  • Chinese (Denver)A;A 51% A;G 21% G;G 28% T;T 0%
  • Gujarati IndianA;A 69% A;G 16% G;G 15% T;T 0%
  • Luhya (Kenya)A;A 37% A;G 29% G;G 34% T;T 0%
  • Mexican ancestry (Los Angeles)A;A 67% A;G 17% G;G 16% T;T 0%
  • Maasai (Kenya)A;A 31% A;G 22% G;G 47% T;T 0%
  • TuscanA;A 74% A;G 13% G;G 14% T;T 0%

Conditions, medicines and genes

Other GRIA3 SNPs

All GRIA3 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

This SNP, located in an intron of the GRIA3 gene (also known as AMPA3), has been linked in one study to increased thoughts of suicide in patients taking the anti-depressant drug citalopram. The increased risk is calculated to be 1.9x. If the individual is also carrying two rs2518224(C) alleles, i.e. is a rs2518224(C;C) homozygote, the odds ratio for having suicidal thoughts is increased to ~15x (CI: 3.7 - 60.6).

Source and license

Adapted from rs4825476 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.