rs1042725

A SNP in the HMGA2 gene on chromosome 12. Its most notable genotype is C;C: ~0.8cm taller

Gene
HMGA2
Location
Chr 1265,964,567 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
43%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot rated~0.8cm tallerMinor · 1.526% of people
  2. C;TNot rated~0.4cm tallerMinor · 1.539% of people
  3. T;TNot ratedAverage heightTypical · 0.035% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 26% C;T 39% T;T 35%
  • European ancestry (Utah)C;C 28% C;T 43% T;T 29%
  • Han Chinese (Beijing)C;C 4% C;T 35% T;T 61%
  • Japanese (Tokyo)C;C 8% C;T 34% T;T 58%
  • Yoruba (Nigeria)C;C 41% C;T 49% T;T 10%
  • African ancestry (Southwest US)C;C 39% C;T 40% T;T 21%
  • Chinese (Denver)C;C 7% C;T 30% T;T 62%
  • Gujarati IndianC;C 9% C;T 44% T;T 47%
  • Luhya (Kenya)C;C 62% C;T 32% T;T 7%
  • Mexican ancestry (Los Angeles)C;C 5% C;T 42% T;T 53%
  • Maasai (Kenya)C;C 55% C;T 40% T;T 6%
  • TuscanC;C 22% C;T 44% T;T 35%

Conditions, medicines and genes

Other HMGA2 SNPs

All HMGA2 SNPs

Notes

From SNPedia

Notes

nature SNP rs1042725 is associated with height (P = 4E-8) in a study involving over 20,000 individuals. The gene harboring this SNP, HMGA2, is a strong biological candidate for having an influence on height, since rare, severe mutations in this gene are known to alter body size in mice and humans. rs1042725 is estimated to explain approx 0.3% of population variation in height in both adults and children (approx 0.4 cm increased adult height per C allele). rs1042725 is associated with increased height (0.36 cm 95% IC[0.12-0.61] per C allele, P=0.004). in men rs1042725 may explain 3% of height variability

C;T

0.4cm taller than average

Source and license

Adapted from rs1042725 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.