rs10784502

A SNP in the HMGA2 gene on chromosome 12. Its most notable genotype is C;C: better intracranial volume?

Gene
HMGA2
Location
Chr 1265,950,030 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
36%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodbetter intracranial volume?Worth knowing · 2.015% of people
  2. C;TGoodSlightly higher intracranial volumeMinor · 1.038% of people
  3. T;TBadless intracranial volume?Minor · 1.547% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 15% C;T 38% T;T 47%
  • European ancestry (Utah)C;C 27% C;T 42% T;T 32%
  • Han Chinese (Beijing)C;C 0% C;T 21% T;T 79%
  • Japanese (Tokyo)C;C <1% C;T 23% T;T 76%
  • Yoruba (Nigeria)C;C 35% C;T 50% T;T 16%
  • African ancestry (Southwest US)C;C 30% C;T 49% T;T 21%
  • Chinese (Denver)C;C 3% C;T 20% T;T 77%
  • Gujarati IndianC;C 8% C;T 35% T;T 57%
  • Luhya (Kenya)C;C 18% C;T 47% T;T 35%
  • Mexican ancestry (Los Angeles)C;C 7% C;T 38% T;T 55%
  • Maasai (Kenya)C;C 15% C;T 50% T;T 35%
  • TuscanC;C 20% C;T 48% T;T 32%

Other HMGA2 SNPs

All HMGA2 SNPs

Notes

From SNPedia

Notes

associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 &#215; 10&#8722;12) http://www.genomesunzipped.org/2012/04/another-iq-gene-new-methods-old-flaws.php (C;C) has higher cranial capacity (about 2 teaspoons) and over 2% higher IQ. (C;T) is half this positive effect. Intelligence

Source and license

Adapted from rs10784502 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.