rs1044396

A SNP in the CHRNA4 gene on chromosome 20. Its most notable genotype is G;G: Increased risk of Nicotine dependence among males

Gene
CHRNA4
Location
Chr 2063,349,782 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
36%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableBadIncreased risk of Nicotine dependence among malesWorth knowing · 2.053% of people

SNPedia records rs1044396 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 53%
  • European ancestry (Utah)G;G 20%
  • Han Chinese (Beijing)G;G 59%
  • Japanese (Tokyo)G;G 39%
  • Yoruba (Nigeria)G;G 92%
  • African ancestry (Southwest US)G;G 63%
  • Chinese (Denver)G;G 54%
  • Gujarati IndianG;G 37%
  • Luhya (Kenya)G;G 91%
  • Mexican ancestry (Los Angeles)G;G 18%
  • Maasai (Kenya)G;G 87%
  • TuscanG;G 26%

Conditions, medicines and genes

Other CHRNA4 SNPs

All CHRNA4 SNPs

Notes

From SNPedia

Notes

associated with vulnerability to nicotine addiction in men. g2b2mh blog rs1044396 mediates effects of nicotine self-medication via parietal cortex. subjects with the (T;T) genotype showed robust brain activity in the parietal cortex while subjects with the (C;C) genotype showed very little change in activity.

Source and license

Adapted from rs1044396 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.