rs1045642(G;G)

Increased risk of cannabis dependence, lower (normal) cancer risk

Magnitude
1.0Minor
Repute
Not rated
Frequency
41%Average of 10 populations
On SNPedia
rs1045642(C;C)Minus strand
Gene
ABCB1

Frequency

Share of people with G;G in each HapMap population.

  • Yoruba (Nigeria)80%
  • Maasai (Kenya)72%
  • African ancestry (Southwest US)63%
  • Han Chinese (Beijing)40%
  • Chinese (Denver)35%
  • Tuscan30%
  • Japanese (Tokyo)28%
  • Mexican ancestry (Los Angeles)26%
  • Gujarati Indian18%
  • European ancestry (Utah)15%

Other genotypes of rs1045642

  1. A;GBadSlower metaboliser for some drugsWorth knowing · 2.044% of people
  2. A;AMost notableBadaltered drug metabolism and bioavailability; moderately increased risk for certain cancersImportant · 3.015% of people

All about rs1045642

Notes

From SNPedia

Association between ABCB1 C3435T polymorphism and increased risk of cannabis dependence. (2009). ncbi.nlm.nih.gov Patients with cannabis dependence (n=40) had a significantly higher 3435C allele frequency (62.5% versus 43.8% respectively, P=0.017) and CC genotype (50% versus 20%, P=0.005, OR=4.00 [1.50-10.60]). The CC genotype was independently associated with cannabis dependence. This is the first time a significant specific genetic marker has been shown in cannabis dependence. ABCB1 polymorphisms may alter Delta9THC distribution, its psychoactive effects and individual vulnerability to dependence.

Source and license

Adapted from rs1045642(C;C) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.