rs104894144

A SNP in the CYP17A1 gene on chromosome 10. Its most notable genotype is C;C: Complete combined 17-alpha-hydroxylase/17,20-lyase deficiency

Gene
CYP17A1
Location
Chr 10102,832,665 (GRCh38)
Highest magnitude
6.6Very important
Tested on
AncestryDNA
Minor allele frequency
<1%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableBadComplete combined 17-alpha-hydroxylase/17,20-lyase deficiencyVery important · 6.6
  2. A;CBadCarrier of a complete combined 17-alpha-hydroxylase/17,20-lyase deficiency mutationImportant · 3.0
  3. A;AGoodcommon in clinvarTypical · 0.0

SNPedia records rs104894144 on the minus strand: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other CYP17A1 SNPs

All CYP17A1 SNPs

Notes

From SNPedia

Notes

c.985T>G (p.Tyr329Asp) 23andMe name: i5001482

C;C

See ClinVar sidebox for citation links

A;C

Unaffected in absence of a second mutation in the CYP17A1 gene

Source and license

Adapted from rs104894144 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.