rs104894561

A SNP in the CSNK1D gene on chromosome 17. Its most notable genotype is C;T: Morning Lark (very early riser)

Gene
CSNK1D
Location
Chr 1782,265,743 (GRCh38)
Highest magnitude
4.0Very important
Tested on
23andMe, AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TGoodcommon in clinvarTypical · 0.0
  2. C;TMost notableNot ratedMorning Lark (very early riser)Very important · 4.0

SNPedia records rs104894561 on the minus strand: (A;A), (A;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs104894561, also known as Thr4Ala or T44A, is a SNP in the casein kinase 1, delta CSNK1D gene. Heterozygotes for rs104894561 have been reported to have a sleep disorder, Familial Advanced Sleep Phase syndrome 2 (FASPS2), and it is therefore considered to be inherited as an autosomal dominant trait. The condition is marked by a ~4 hour shift towards earlier bedtime and rising time compared to most people.

C;T

This genotype is associated with a sleep disorder known as Familial Advanced Sleep Phase Sydrome 2 (FASPS2), in which individuals go to bed (and rise) about 4 hours earlier than most people.

Source and license

Adapted from rs104894561 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.