rs397514693
A SNP in the CSNK1D gene on chromosome 17. Its most notable genotype is C;T: Morning Lark (very early riser)
- Gene
- CSNK1D
- Location
- Chr 1782,265,736 (GRCh38)
- Highest magnitude
- 4.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs397514693 on the minus strand: (A;A), (A;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 120 words
rs397514693, also known as His46Arg or H46R, is a SNP in the casein kinase 1, delta CSNK1D gene. Heterozygotes for rs397514693 have been reported to have a sleep disorder, Familial Advanced Sleep Phase syndrome 2 (FASPS2), and it is therefore considered to be inherited as an autosomal dominant trait. The condition is marked by a ~4 hour shift towards earlier bedtime and rising time compared to most people. There is also a report that finds a complex connection to migraine in association with this SNP, requiring further study.
C;T
This genotype is associated with a sleep disorder known as Familial Advanced Sleep Phase Sydrome 2 (FASPS2), in which individuals go to bed (and rise) about 4 hours earlier than most people.
Source and license
Adapted from rs397514693 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.