rs1061235

A SNP in the HLA-A gene on chromosome 6. Its most notable genotype is T;T: 26% risk of bad reaction to anti-epileptic carbamazepine

Gene
HLA-A
Location
Chr 629,945,521 (GRCh38)
Highest magnitude
4.0Very important
Tested on
23andMe, AncestryDNA
Minor allele frequency
7%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodNormal carbamazepine sensitivity; common in clinvarTypical · 0.1
  2. A;TBad26% risk of bad reaction to anti-epileptic carbamazepineWorth knowing · 2.9
  3. T;TMost notableBad26% risk of bad reaction to anti-epileptic carbamazepineVery important · 4.0

On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other HLA-A SNPs

All HLA-A SNPs

Notes

From SNPedia

Notes

rs1061235(T) serves as a proxy for the HLA-A*3101 allele. The HLA-A*3101 allele, found in about 2 - 5% of Northern Europeans, is significantly associated with carbamazepine hypersensitivity syndrome, with odds ratios above 10. The presence of this HLA allele increases the risk from 5% to 26%, whereas its absence reduces the risk from 5% to 4%.

Source and license

Adapted from rs1061235 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.