rs10735781

A SNP in the EVI5 gene on chromosome 1. Its most notable genotype is C;C: >1.11x risk

Gene
EVI5
Location
Chr 192,655,550 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
35%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot rated>1.11x riskTypical · 0.046% of people
  2. C;GNot rated1.11x riskTypical · 0.035% of people
  3. G;GNot ratedcommonTypical · 0.019% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 46% C;G 35% G;G 19%
  • European ancestry (Utah)C;C 43% C;G 46% G;G 12%
  • Han Chinese (Beijing)C;C 86% C;G 13% G;G <1%
  • Japanese (Tokyo)C;C 90% C;G 9% G;G <1%
  • Yoruba (Nigeria)C;C 11% C;G 41% G;G 48%
  • African ancestry (Southwest US)C;C 19% C;G 54% G;G 26%
  • Chinese (Denver)C;C 79% C;G 20% G;G <1%
  • Gujarati IndianC;C 61% C;G 34% G;G 5%
  • Luhya (Kenya)C;C 8% C;G 45% G;G 47%
  • Mexican ancestry (Los Angeles)C;C 52% C;G 41% G;G 7%
  • Maasai (Kenya)C;C 13% C;G 43% G;G 44%
  • TuscanC;C 44% C;G 43% G;G 13%

Conditions, medicines and genes

Other EVI5 SNPs

All EVI5 SNPs

Notes

From SNPedia

Notes

rs10735781 has been reported in a large study to be associated with multiple sclerosis. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with this allele is 1.11 (CI 1.05-1.18). An application of Random Forests to a genome-wide association dataset: methodological considerations & new findings.

Source and license

Adapted from rs10735781 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.