rs6680578

A SNP in the EVI5 gene on chromosome 1. Its most notable genotype is A;A: >1.11x risk

Gene
EVI5
Location
Chr 192,711,321 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
36%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot rated>1.11x riskTypical · 0.046% of people
  2. A;TNot rated1.11x riskTypical · 0.035% of people
  3. T;TNot ratedcommonTypical · 0.019% of people

On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 46% A;T 35% T;T 19%
  • European ancestry (Utah)A;A 45% A;T 43% T;T 12%
  • Han Chinese (Beijing)A;A 85% A;T 13% T;T 2%
  • Japanese (Tokyo)A;A 90% A;T 9% T;T <1%
  • Yoruba (Nigeria)A;A 11% A;T 42% T;T 48%
  • African ancestry (Southwest US)A;A 18% A;T 55% T;T 27%
  • Chinese (Denver)A;A 80% A;T 18% T;T 2%
  • Gujarati IndianA;A 60% A;T 35% T;T 5%
  • Luhya (Kenya)A;A 7% A;T 46% T;T 47%
  • Mexican ancestry (Los Angeles)A;A 54% A;T 39% T;T 7%
  • Maasai (Kenya)A;A 12% A;T 42% T;T 46%
  • TuscanA;A 46% A;T 41% T;T 13%

Conditions, medicines and genes

Other EVI5 SNPs

All EVI5 SNPs

Notes

From SNPedia

Notes

rs6680578 has been reported in a large study to be associated with multiple sclerosis. The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with this allele is 1.11 (CI 1.04-1.17).

Source and license

Adapted from rs6680578 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.