rs10741657

A SNP in the LOC107984314 gene on chromosome 11. Its most notable genotype is G;G: tend to have lower vitamin D levels

Gene
LOC107984314
Location
Chr 1114,893,332 (GRCh38)
Highest magnitude
1.3Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
33%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratedtend to have higher vitamin D levelsMinor · 1.012% of people
  2. G;GMost notableNot ratedtend to have lower vitamin D levelsMinor · 1.344% of people

On SNPedia: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 12% G;G 44%
  • European ancestry (Utah)A;A 16% G;G 39%
  • Han Chinese (Beijing)A;A 13% G;G 41%
  • Japanese (Tokyo)A;A 16% G;G 36%
  • Yoruba (Nigeria)A;A 2% G;G 58%

Conditions, medicines and genes

Other LOC107984314 SNPs

All LOC107984314 SNPs

Notes

From SNPedia

Notes

rs10741657, located near the cytochrome P450, family 2, subfamily R, polypeptide 1 CYP2R1 gene on chromosome 11p15, has been linked by several studies to vitamin D serum concentrations. In both studies, the allele associated with lower vitamin D, and thus the potential for vitamin D insufficiency, is rs10741657(G). Carriers of two such alleles have lower vitamin D than carriers of one allele, who in turn on average have lower vitamin D levels than rs10741657(A;A) individuals. The 'A' allele of CYP2R1 rs10741657 was associated with increased 25(OH)D levels in a study of vitamin D levels and MS risk in 1,655 cases and 6,349 controls.

Source and license

Adapted from rs10741657 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.