rs10816625

A SNP in the LOC105376214 gene on chromosome 9. Its most notable genotype is A;G: slightly increased risk for breast cancer (1.12x)

Gene
LOC105376214
Location
Chr 9108,074,792 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon/normalTypical · 0.072% of people
  2. A;GMost notableBadslightly increased risk for breast cancer (1.12x)Minor · 1.522% of people
  3. G;GBadslightly increased risk for breast cancer (1.24x)Minor · 1.57% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 72% A;G 22% G;G 7%
  • European ancestry (Utah)A;A 84% A;G 13% G;G 3%
  • Han Chinese (Beijing)A;A 24% A;G 52% G;G 24%
  • Japanese (Tokyo)A;A 37% A;G 50% G;G 12%
  • Yoruba (Nigeria)A;A 100% A;G 0% G;G 0%
  • African ancestry (Southwest US)A;A 95% A;G 5% G;G 0%
  • Chinese (Denver)A;A 31% A;G 51% G;G 18%
  • Gujarati IndianA;A 81% A;G 18% G;G 1%
  • Luhya (Kenya)A;A 98% A;G 2% G;G 0%
  • Mexican ancestry (Los Angeles)A;A 57% A;G 31% G;G 12%
  • Maasai (Kenya)A;A 99% A;G <1% G;G 0%
  • TuscanA;A 83% A;G 16% G;G 1%

Conditions, medicines and genes

Other LOC105376214 SNPs

All LOC105376214 SNPs

Notes

From SNPedia

Notes

rs10816625 is a SNP in a region of chromosome 9q31.2 that has been associated with breast cancer. In a pooled study of 52 studies totalling 43,160 breast cancer cases in women of European ancestry, plus a further 5795 cases of Asian ancestry, the rs10816625(G) allele was independently associated with increased risk in both Europeans (odds ratio 1.12, CI:1.08-1.17, p = 7.89 &#215; 10e-9) and Asians (odds ratio 1.12, CI:1.06-1.18, p = 2.77 &#215; 10e-5).

A;G

see discussion at rs10816625

G;G

see discussion at rs10816625

Source and license

Adapted from rs10816625 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.