rs13294895

A SNP in the LOC105376214 gene on chromosome 9. Its most notable genotype is C;T: slightly increased risk for breast cancer (1.09x)

Gene
LOC105376214
Location
Chr 9108,074,895 (GRCh38)
Highest magnitude
1.4Minor
Tested on
23andMe, FamilyTreeDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon/normalTypical · 0.086% of people
  2. C;TMost notableBadslightly increased risk for breast cancer (1.09x)Minor · 1.413% of people
  3. T;TBadslightly increased risk for breast cancer (1.18x)Minor · 1.41% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 86% C;T 13% T;T 1%
  • European ancestry (Utah)C;C 66% C;T 31% T;T 4%
  • Han Chinese (Beijing)C;C 95% C;T 4% T;T <1%
  • Japanese (Tokyo)C;C 97% C;T 4% T;T 0%
  • Yoruba (Nigeria)C;C 100% C;T 0% T;T 0%
  • African ancestry (Southwest US)C;C 83% C;T 18% T;T 0%
  • Chinese (Denver)C;C 94% C;T 6% T;T 0%
  • Gujarati IndianC;C 72% C;T 25% T;T 3%
  • Luhya (Kenya)C;C 98% C;T 2% T;T 0%
  • Mexican ancestry (Los Angeles)C;C 81% C;T 16% T;T 3%
  • Maasai (Kenya)C;C 89% C;T 12% T;T 0%
  • TuscanC;C 69% C;T 28% T;T 3%

Conditions, medicines and genes

Other LOC105376214 SNPs

All LOC105376214 SNPs

Notes

From SNPedia

Notes

rs13294895 is a SNP in a region of chromosome 9q31.2 that has been associated with breast cancer. In a pooled study of 52 studies totalling 43,160 breast cancer cases in women of European ancestry, plus a further 5795 cases of Asian ancestry, the rs13294895(T) allele was independently associated with increased risk in Europeans (odds ratio 1.09, CI:1.06-1.12, p = 2.97 &#215; 10e-11) but not in Asians.

C;T

see discussion at rs13294895

T;T

see discussion at rs13294895

Source and license

Adapted from rs13294895 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.