rs10897346

A SNP on chromosome 11. Its most notable genotype is C;C: If depressed, 2.6x more likely to not respond to antidepressants

Gene
None listed
Location
Chr 1155,863,349 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadIf depressed, 2.6x more likely to not respond to antidepressantsImportant · 3.0
  2. C;TBadIf depressed, 2.6x more likely to not respond to antidepressantsImportant · 3.0
  3. T;TGoodnormalTypical · 0.0

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

Carriers of rs10897346(C) alleles showed a 2.6-fold increased risk (CI: 1.4-4.8) for nonresponse to all major types of anti-depressant drugs (such as the SSRI drug citalopram) in a study of 182 German patients. Pharmacogenetics of antidepressant response.

Source and license

Adapted from rs10897346 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.