rs10918594

A SNP in the NOS1AP gene on chromosome 1. Its most notable genotype is C;C: Shorter QT interval

Gene
NOS1AP
Location
Chr 1162,060,898 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
43%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedShorter QT intervalTypical · 0.0
  2. C;GNot ratedaverage QT intervalTypical · 0.0
  3. G;GNot ratedLonger QT intervalTypical · 0.0

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other NOS1AP SNPs

All NOS1AP SNPs

Notes

From SNPedia

Show notes, about 180 words

rs10918594, a SNP near the NOS1AP gene encoding the nitric oxide synthase I protein, accounts for some of the variation seen in abnormal heart rhythms, in particular, the QT interval. Based on studies totaling ~4,000 individuals of Caucasian ancestry, homozygotes for one allele have shorter QT intervals, while homozygotes for the other allele have a longer QT interval. A follow-up study determined that one rs10918594(G) allele was associated with a 3.6-ms (CI: 2.7 - 4.4ms, p=6.9x10(-17)) increase in QT interval duration, and two (G) alleles had twice that increase. No increase in risk for sudden death due to a cardiac problem was associated with this SNP, though. rs10494366 minor homozygotes had a 9.3 msec longer QT interval compared to major homozygotes (p=5.7x10(-5)); rs10918594 minor homozygotes had a 12.5 msec longer QT interval compared to major homozygotes (p=1.5x10(-6)). Restricting analyses to the diabetic EAs strengthened the effect despite the reduction in sample size (11.3 msec difference, p=5.1x10(-5); 13.9 msec difference, p=1.6x10(-6), respectively).

Source and license

Adapted from rs10918594 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.