rs10954174

A SNP in the LEP gene on chromosome 7. Its most notable genotype is A;A: common in clinvar

Gene
LEP
Location
Chr 7128,256,483 (GRCh38)
Highest magnitude
0.0Typical
Tested on
AncestryDNA
Minor allele frequency
4%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodcommon in clinvarTypical · 0.0<1% of people
  2. G;GGoodcommon in complete genomicsTypical · 0.089% of people

On SNPedia: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 9 HapMap populations.

  • AverageA;A <1% G;G 89%
  • European ancestry (Utah)A;A 0% G;G 100%
  • Han Chinese (Beijing)A;A <1% G;G 96%
  • Japanese (Tokyo)A;A 0% G;G 92%
  • Yoruba (Nigeria)A;A 3% G;G 79%
  • African ancestry (Southwest US)A;A 0% G;G 74%
  • Chinese (Denver)A;A 0% G;G 95%
  • Gujarati IndianA;A 0% G;G 99%
  • Luhya (Kenya)A;A 0% G;G 79%
  • Maasai (Kenya)A;A <1% G;G 85%

Other LEP SNPs

All LEP SNPs

Source and license

Adapted from rs10954174 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.